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KMID : 0359319940340030471
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Korean Journal of Veterinary Research
1994 Volume.34 No. 3 p.471 ~ p.478
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Effects of histamine on the ruminal smooth muscle motility of cattle
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Abstract
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Effects of histamine on the ruminal smooth muscle motility of cattle were investigated in the longitudinal and circular smooth muscle strips. In order to these experiments, specimens were obtained from 35 korean native cattles, 3-4 years old, in Kwang-ju area slaughterhouse. Smooth muscle strips of rumen were made from sample, and then measured the isometric contraction with physiograph in 37℃ organ bath. The results were as follows
1. Histamine caused two different types of response(a contraction or a relaxation) on the smooth muscle of cattle rumen. These responses increased in dose dependant manner.
2. Pyrilamine(H₁receptor antagonist) completely blocked contraction in all the preparation and converted the response into relaxation.
3. Cimetidine(H₂-receptor antagonist) completely blocked relaxation in all the preparation and converted the response into contraction.
4. 1´he contraction induced by histamine(10^(-3)M) was not Mocked by chofinergic, adrenergic blocker or hexamethonium.
5. The contraction induced by histamine(10^(-3)M) was markedly inhibited in the Ca^(2+) free(or EDTA·2Na) Kreb´s solution and by verapamil.
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